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VIDEO LIBRARY

Administration Video

Watch a healthcare professional demonstrate how to administer a deep subcutaneous injection with the Somatuline® Depot syringe. Please see Instructions for Use located in the full Prescribing Information for a complete list of administration steps.

Administration Video

Watch a healthcare professional demonstrate how to administer a deep subcutaneous injection with the Somatuline® Depot syringe. Please see Instructions for Use located in the full Prescribing Information for a complete list of administration steps.

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Somatuline Depot Formulation Video

See how Somatuline Depot is specially formulated to help streamline preparation and administration. Also includes the mechanism of action of lanreotide, an octapeptide analog of natural somatostatin.

Somatuline Depot Formulation Video

See how Somatuline Depot is specially formulated to help streamline preparation and administration. Also includes the mechanism of action of lanreotide, an octapeptide analog of natural somatostatin.

Watch Now

NETs Neuroendocrine Expert Talks Podcast Series

Listen to diagnostic and treatment advice from key opinion leaders as they discuss hypothetical patient scenarios. The healthcare professionals in these podcasts are paid consultants for Ipsen.

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NETs Neuroendocrine Expert Talks Podcast Series

Listen to diagnostic and treatment advice from key opinion leaders as they discuss hypothetical patient scenarios. The healthcare professionals in these podcasts are paid consultants for Ipsen.

Listen Now

IMPORTANT SAFETY INFORMATION & INDICATIONS

Contraindications

  • SOMATULINE DEPOT is contraindicated in patients with hypersensitivity to lanreotide. Allergic reactions (including angioedema and anaphylaxis) have been reported following administration of lanreotide.

Warnings and Precautions

  • Cholelithiasis and Gallbladder Sludge
    • SOMATULINE DEPOT may reduce gallbladder motility and lead to gallstone formation.
    • Periodic monitoring may be needed.
    • If complications of cholelithiasis are suspected, discontinue SOMATULINE DEPOT and treat appropriately.
  • Hypoglycemia or Hyperglycemia
    • Patients treated with SOMATULINE DEPOT may experience hypoglycemia or hyperglycemia.
    • Blood glucose levels should be monitored when SOMATULINE DEPOT treatment is initiated, or when the dose is altered, and antidiabetic treatment should be adjusted accordingly.
  • Cardiovascular Abnormalities
    • SOMATULINE DEPOT may decrease heart rate.
    • In patients without underlying cardiac disease, SOMATULINE DEPOT may lead to a decrease in heart rate without necessarily reaching the threshold of bradycardia.
    • In patients suffering from cardiac disorders prior to treatment, sinus bradycardia may occur. Care should be taken when initiating treatment in patients with bradycardia.

Most Common Adverse Reactions

  • GEP-NETs: Adverse reactions in >10% of patients who received SOMATULINE DEPOT were abdominal pain (34%), musculoskeletal pain (19%), vomiting (19%), headache (16%), injection site reaction (15%), hyperglycemia (14%), hypertension (14%), and cholelithiasis (14%).
  • Carcinoid Syndrome: Adverse reactions occurring in the carcinoid syndrome trial were generally similar to those in the GEP-NET trial. Adverse reactions in ≥5% of patients who received SOMATULINE DEPOT and at least 5% greater than placebo were headache (12%), dizziness (7%) and muscle spasm (5%).

Drug Interactions

  • SOMATULINE DEPOT may decrease the absorption of cyclosporine (dosage adjustment may be needed); increase the absorption of bromocriptine; and require dosage adjustment for bradycardia-inducing drugs (e.g., beta-blockers).

Special Populations

  • Lactation: Advise women not to breastfeed during treatment and for 6 months after the last dose.

To report SUSPECTED ADVERSE REACTIONS, contact Ipsen Biopharmaceuticals, Inc. at 1-855-463-5127 or FDA at 1-800-FDA-1088 or www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program.

INDICATIONS

  • SOMATULINE® DEPOT (lanreotide) is a somatostatin analog indicated for: the treatment of adult patients with unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) to improve progression-free survival; and
  • the treatment of adults with carcinoid syndrome; when used, it reduces the frequency of short-acting somatostatin analog rescue therapy.

Please click here for the full Prescribing Information and Patient Information.

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Somatuline Depot is a registered trademark of Ipsen Pharma S.A.S.
IPSEN CARES is a registered trademark of Ipsen S.A.
All other trademarks and registered trademarks are the property of their respective owners.

© 2023 Ipsen Biopharmaceuticals Inc. All rights reserved. September 2023. SMD-US-003607 v3.0.